Where to rent car in Edinburgh as an American driving in the UK for the first time?

Hello,

My family and I will be traveling around the UK this coming fall and part of our itinerary includes renting a car in Edinburgh before driving through and exploring the Highlands. Never having driven on the left side of the road before, I was wondering if I would be better off renting a car on the outskirts of town rather than the inner city. Is getting out of Edinburgh very difficult for someone of my circumstance? For convenience sake I'd prefer to rent within the city since that is where we will be staying for a few nights prior but would be open to getting an Uber to a different pickup location if that was the general recommendation.

Thanks