Best cruising&long distance frame

Hi, I have been skating aggressive for 20+ years and a 4x100 frame for the last 3 years. I want to get a new frame mostly for cruising around the city, but also for training for the an inline marathon. I am not planning to use it for any kind of tricks. Which is the frame setup you would recommend? 4x100/4x110/3x110/3x125? Thank you!