How crazy can a "peak" human get in WoD?

So since the recent episode people have been speculating on what exactly big D is since he went toe toe with a werewolf, albeit for a short amount of time. But how funny and in keeping with the show would it be if he was just human. I know there's some crazy artifacts in WoD a human can use. But I haven't played and don't know what power a hunter can get to if you let them essentially win campaign after campaign.