Finally managed to take down a Medium demolisher without losing a turret!
My "worm killer" has a chest with one iron plate between the 2 rows of turrets, and the turrets set to enable when iron plates = 0. It's worked fairly well so far but I usually lose one or 2 turrets to some splash damage. I'm thinking I may need to make it a bit wider and use 2 chests instead of 1.