FDA audits and NTFs; other focal points

I have heard Senior CRAs steer sites away from NTFs for most things. They’ll say, “clarify in a site memo”. First off, is this really any different and how?

Second, for those of you with FDA Audit experience, please elaborate on your experience with FDA disdain for NTFs if you experienced this. Or if you have any other input here pertaining to strange findings or overall things to help your sites avoid?

I came from site level wither NTFs “fixed everything”, I’ve been a CRA now for 2 years, and want to be able to give my sites real world (today’s FDA world) input. TIA!