Bringing CR Work In-House

If you are on the sponsor end (and not part of a huge company like Pfizer for example), have you had success internalizing any clinical research activities? For example, IHCRA, DM, PV, MW.

My company is exploring bringing work from different CROs and vendors in house due to cost and quality. We have key people in various clin ops/dev/PV roles, but we want to be realistic about our ability to build out a team to support multiple clinical trials and if internalizing work will cause more headache than it's worth. Curious to hear everyone's thoughts and pros and cons that you have experienced.