Taking probiotics when your meds lose their effectiveness.

So I have taken many medications per day.

Carbamazepine 1200mg Pregabalin Lamartine 400mg Mylan 2.4g

For a while they work like magic going down from pain 10 to 0. Then all of a sudden the pain returns despite the medication.

As this is an absorption problem where you meditation after taking it doesn’t absorb and the active ingredient doesn’t metabolise properly in the blood stream, could taking probiotics work to then allow the meds to start working again?