Has anyone done whole genome sequencing (WGS)?
After 10 rounds of IVF and 4 miscarriages, we still don’t know why we can’t seem to get a live birth. There are several possibilities and solutions for them:
My antiphospholipid syndrome making it difficult to sustain a pregnancy -> try different medications
My antiphospholipid syndrome or some other issue with my body making it impossible to sustain a pregnany -> surrogacy
Sperm issues that can’t be changed -> no possibility for a biological child (no male relatives)
Egg issues that can’t be changed -> use a close female relative as an egg donor
The first possibility is the only one we can easily try without knowing for sure what the real issue is. Surrogacy is expensive and there are possible ethical concerns. Asking my female relative to donate is a big favour to ask for, even though she has agreed to do it if it’s our only option. The third possibility would mean to live childless, break up or use a donor (which would be a big risk, since my partner isn’t sure how he would feel about a donor-conceived child - I risk becoming a single parent).
So how do we figure out what the issue is? I heard about whole genome sequencing (WGS) and now I’m hoping it will be the solution to our problems, by identifying genes that point in one of the four directions listed above. Has anyone else used it? Was it helpful? Any other advice on what we should do?