How feasible would a train base be?

Recently thought about how cool it would be to have my entire setup on a moving train and started planning out what I'd need to do in my head, but I quickly ran into the issue of "How would stuff even work if it's on a moving contraption?"

I'm fairly certain accessing storage wouldn't be possible while the train is a moving contraption, nor would I be able to interact with machines by hand.
How feasible is this idea? I'd really like to do it but I just feel like it would be REALLY rough around the edges...