How long

So I start mono therapy last week, 4mg estradiol valerate IM weekly. Before that I was testosterone replacement therapy, I had to wait for my testosterone levels to drop before my first injection. I’m definitely feeling different, a bit more emotional which is nice as I was completely numb while on testosterone. But starting earlier this week my whole body has been achy, nothing major a couple ibuprofen a day makes it go away. Is this normal and any idea on how long it lasts?