Don't be an idiot.
I've been chasing extrusion issues the last couple of days and it's been driving me insane. Adjust the Z. Adjust the flow. Adjust the line widths. Check for clogs. Then do it all over because nothing seems to make the darn thing print consistently.
Well, my machine is in my bedroom. I laid down last night and glanced over at it before turning out the light.
BOOM! Right there plain as the nose on my face was the reason. Last weekend I checked my rotation distance (e-steps). And I stuck a piece of tape on the filament to mark my measurement. Yup, it was still there around the filament. Causing just enough drag to throw everything off.
Don't be an idiot like me.